The US first used the Vaccine Adverse Event Reporting System, and then a newer, web based system for active surveillance. Currently, large, population based systems are used for monitoring, including the newly established Post licensure Rapid Immunization Safety Monitoring project and the Vaccine Safety Datalink project, linking computerised vaccination data with healthcare encounter codes.3 4 5The resulting amount of data for the safety of pandemic H1N1 vaccines among children and adolescents is enormous, but diversity in methods and data presentation has hampered the safety analyses.2 Other research has stressed the importance of identifying background rates of selected diseases to distinguish between events temporally occurring and those causally linked to mass vaccination.6 7 8 Earlier experiences have shown how reports of particular adverse events associated with vaccination can rapidly affect vaccine acceptance.9 10Using unique Danish medical administrative databases pandora charms, we provide background rates of selected outcomes in a population given standard childhood vaccinations, to help in the causality assessment of adverse events related to a novel vaccine being introduced into a mass immunisation programme.MethodsStudy design and study populationThis nationwide population based cohort study included all liveborn infants who were delivered in Denmark between 1 January 1980 and 31 December 2009. Study participants were followed from date of birth until the first recorded hospital admission for the earliest date of the following events: one of the selected outcome diagnoses in table 1 https://www.pandoracharmsonsale.ca/, death, first emigration, age 18 years, or 31 December 2009.
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